Dr. Alex Polotsky

Dr. Alex Polotsky

Associate Professor, Obstetrics and Gynecology
Director, Reproductive Endocrinology and Infertility Fellowship


Group affiliation:
University of Colorado Department of Obstetrics and Gynecology

Practice Location:

Dr. Alex Polotsky

Dr. Polotsky completed his undergraduate studies at University of Maryland and received his medical degree from the Albert Einstein College of Medicine in Bronx, New York. He completed his residency in Obstetrics and Gynecology at New York Presbyterian Hospital – Cornell Medical Center and his fellowship at the Albert Einstein College of Medicine. Subsequently, Dr. Polotsky has earned his Master’s of Science degree in Clinical Research at Albert Einstein College of Medicine. His thesis explored the links between the adolescent obesity and reduced lifetime fertility. Dr. Polotsky joined the faculty at the University of Colorado in 2010.

He actively publishes in many areas of reproductive endocrinology. He recently co-authored a chapter entitled “Nutrition and the Pubertal Transition” for the Yen and Jaffe’s Reproductive Endocrinology, one of the most recommended books in the field, along with Dr. Santoro. In his free time, Dr. Polotsky enjoys skiing, biking and hiking with his wife and five children.

Find Dr. Polotsky on Google Plus

Specialties:

Dr. Polotsky clinical interests include infertility, assisted reproductive technologies, obesity and its influence of fertility, amenorrhea, adolescent gynecology, and endometrial disorders.

Dr. Polotsky is board certified in Obstetrics & Gynecology and Reproductive Endocrinology & Infertility

 

 

 

 

 

 

 

Meet Dr. Polotsky

Education

9/1989-1/1992    Ivan Pavlov Medical University, St. Petersburg, Russia
9/1992-12/1992  University of Maryland Baltimore County, Baltimore, MD
1/1993-12/1993  University of Maryland, College Park, MD, B. S., Biology
8/1996-6/2000    Albert Einstein College of Medicine, Bronx, NY, M.D.
7/2000-6/2004    New York Presbyterian Hospital –Cornell, New York, NY
Internship and Residency, Obstetrics and Gynecology
7/2004-6/2007    Albert Einstein College of Medicine, Bronx, NY
Fellowship, Reproductive Endocrinology and Infertility
7/2005-6/2007    Albert Einstein College of Medicine, Bronx, NY
                            M. Sc. in Clinical Research Methods, Clinical Research Training Program

Academic Appointments

Full-Time Faculty Positions:
2004-2007       Instructor, Obstetrics and Gynecology, Albert Einstein College of Medicine, Bronx, NY
2007-2010       Assistant Professor, Obstetrics and Gynecology, Albert Einstein College of Medicine, Bronx, NY
2010-2012       Assistant Professor, Obstetrics and Gynecology, School of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO
2012-present  Associate Professor, Obstetrics and Gynecology, School of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO

Adjunct Faculty Position:
2011-present  Graduate Faculty Appointment, Clinical Science Graduate Degree Program, Graduate School, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO

Hospital and Professional Positions 

1994-1996       Research Assistant, Georgetown University Medical Center, Washington, DC
2004-2010       Attending Physician, Montefiore Medical Center, Bronx, NY
2010-present   Attending Physician, University of Colorado Hospital, Aurora, CO

Hospital Privileges:
2004-2010       Montefiore Medical Center, Bronx, NY
2004-2010       North Bronx Healthcare Network, Jacobi & N Central Bronx Hospital
2007-2010       St. John’s Riverside Hospital, Dobbs Ferry Pavilion, Dobbs Ferry, NY
2008-2010       Phelps Memorial Hospital Center, Sleepy Hollow, NY
2010-present  University of Colorado Hospital, Aurora, CO

Honors, Special Recognitions and Awards

1992-1993       Dean’s List, University of Maryland
1993                Golden Key National Undergraduate Honor Society
1996-2000       Louis and Rachel Rudin Scholarship (AECOM)
1998-2000       Lurie Foundation Scholarship (AECOM)
2005                Endocrine Society Workshop for Trainees Travel Award
2005-2007       NIH/Society for Reproductive Endocrinology/Infertility T32 Grant Recipient
2007-2010       DewPoint Scholar (Division of Equity in Women’s & Perinatal Medicine)
2011-2013       NIH/NICHD, Loan Repayment Program, Infertility and Contraception
2011                American Association of Obstetricians and Gynecologists Foundation (AAOGF)/American Gynecological and Obstetrical Society (AGOS) Travel Award,
2011                AGOS Annual Meeting
2011                Person of the Year 2011,Community Service Award, Gorizont Newspaper, Denver

Membership and Leadership Positions in Professional Organizations

2001-2008       American College of Obstetricians and Gynecologists (ACOG), Junior Member
2003-present   American Society for Reproductive Medicine (ASRM), Member
2005-present   Endocrine Society, Member
2006-present   Society for Reproductive Endocrinology and Infertility (SREI), Member
2008-present   American College of Obstetricians and Gynecologists (ACOG), Fellow
2009                Obesity and Reproduction, Round Table Leader, ASRM
2009                Special Fellow Research Discussant and Session Chair, ASRM
2011                Menopause Day Abstracts Session Chair, ASRM
2012                Reproductive Endocrinology and Infertility Oral Abstracts Session Chair, SGI
2012                Nutrition Oral Abstracts Session Chair, ASRM
2012                Clinical Female Infertility/Gynecology Oral Abstracts Session Chair,  ASRM

Major Committee and Service Responsibilities

Departmental Committee Appointments:
2007-2010       Faculty Director for Fellow Clinical Journal Club, Reproductive Endocrinology & Infertility, Albert Einstein College of Medicine
2010-present  Faculty Co-Director for Fellow Clinical Journal Club, Reproductive Endocrinology and Infertility, University of Colorado
2010-present  Department of OB/GYN Institutional Review Board Liaison

School of Medicine, University and Hospital Committee Appointments:
2006-2007       University Hospital Credentialing Committee, House Staff Representative, Montefiore Medical Center
2009-2010       Ad-hoc Member, Thesis Review Committee, Clinical Research Training Program, Albert Einstein College of Medicine
2010-present  Institutional Review Board Member, COMIRB, University of Colorado
2011-present  Clinical Translational Research Advisory Committee (CTRAC), University of Colorado
2011,2012       Women’s Health Research Day Poster Judge, University of Colorado

National Committee Appointments:
2010-2012       Society for Gynecological Investigation, Annual Meeting Abstract Reviewer
2010-current   American Diabetes Association Research Grant Review Committee (RGRC) (term: 2011-2013)
2011                External Advisory Board Member, Wake Forest University Primate Center, Winston-Salem, NC
2011                New Studies Committee, Member, Study of Women’s Health Across the Nation (SWAN)
2011, 2012      American Society for Reproductive Medicine, Abstract Review Committee

Licensure and Board Certification

State of Colorado (active)
State of New York (inactive)
State of New Jersey (inactive)
Board in Obstetrics and Gynecology, November 2007, recertified in 2010, 2011, 2012
Board in Reproductive Endocrinology and Infertility, April 2009, recertified in 2010, 2011, 2012     

Industrial Consultant/Collaborator

2008    RealCME.com, Irregular Periods and Increased Body Hair Module Consultant
2008    Transdermal Labs Corp, New York, NY, Consultant for Vitamin Supplement Development
2008    Merck, Whitehouse Station, NJ, Consultant for Ovarian Effects for Drug Development
2011    Ferring Pharmaceuticals, Parsippany, NJ, Consultant for GnRH Product Development

Review and referee work

Grant Review Panels:
2011-2013       Research Grant Review Committee Member, American Diabetes Association
2012                Special Emphasis Panel, ZHD1 DSR-L 40, NICHD Specialized Cooperative Centers Program in Reproduction and Infertility Research (U54) Review, National Institute of Child Health and Human Development

Peer-Reviewed Journal Reviewer:
Maturitas
Human Reproduction
Fertility and Sterility
International Archives of Medicine
Systems Biology in Reproductive Medicine
American Journal of Obstetrics and Gynecology
Reproductive Sciences
Journal of Reproductive Medicine
Menopause
Obstetrics and Gynecology
Reproductive Biomedicine Online
Journal of Women’s Health
American Journal of Epidemiology
European Journal of Obstetrics & Gynecology and Reproductive Biology
Journal of Assisted Reproduction and Genetics
British Medical Journal (BMJ)
Reproductive Biology and Endocrinology
Journal of Clinical Endocrinology & Metabolism

11. Invited Lectures and Presentations

2005    Effects of Bariatric Surgery on Adipokines and Reproductive Function, Endocrine Society Workshop for Trainees, Boston, MA
2007    Impact of Adolescent Obesity on Lifetime Parity, Ob/Gyn Grand Rounds, Albert Einstein College of Medicine, Bronx, NY
2007    Effects of Modulation of the Endometrial Cell Cycle on Xenografted Human Endometrium, Society for Reproductive Endocrinology (SREI) Special Research Presentation, Washington, DC
2009    Epidemiology and Pathophysiology of Obesity and Reproduction in Women, Wake Forest University Reproductive Symposium, Winston-Salem, NC
2009    Obesity and Reproduction in Men, Women, Monkeys, University of Colorado, Aurora, CO
2009    Beyond the Scale: Obesity and Diminished Reproductive Performance, Autumn in New York Postgraduate Symposium for Ob/Gyn, New York, NY
2010    Premature Ovarian Failure, Pediatric Endocrinology Grand Rounds, Montefiore Medical Center, Bronx, NY
2010    Managing Menopause, Family Medicine Review, University of Colorado, Aurora CO
2010    Link between Obesity and Reproduction: in Quest of the Holy Grail, Program in Reproductive Sciences, University of Colorado, Aurora, CO
2011    Sleep Apnea and Reproductive Hormones, Sleep Medicine Grand Rounds, National Jewish Hospital, Denver, CO
2011    Obesity and Reproduction, University of Colorado Denver OB/Gyn Review,Vail, CO
2011    Obesity and Reproductive Impairment: Cause and Effect Relationship? Neuroendocrine Focus Group Meeting, Specialized Cooperative Centers Program in Reproduction and Infertility Research (SCCPIR), NIH/NICHD symposium, Chicago, IL
2011    Obesity and Reproduction, The University of Texas Health Science Center at San Antonio, Ob/Gyn Grand Rounds, San Antonio, TX
2011    Vervet Monkey as a Model of Human Reproductive Disease, Wake Forest Baptist Medical Center, Winston-Salem, NC
2012    Adverse Effects of Obesity on Reproduction: Can Sleep Apnea Play a Role, Division of Sleep Medicine, Johns Hopkins University School of Medicine, Baltimore, MD
2012    Hot Topics Panel, Neuroendocrine Focus Group, Specialized Cooperative Centers Program in Reproduction and Infertility Research (SCCPIR), NIH/NICHD, Bethesda, MD

Teaching Record

2006-2010       3rd Yr Medical Student Ob/Gyn Clerkship, Albert Einstein, 6/year
2007-2010       REI Fellowship Journal Club, Albert Einstein, monthly
2007-2010       2nd Yr Medical Student Small Group Preceptor, Albert Einstein, 4/year
2010-present  REI Fellowship Journal Club, University of Colorado, monthly
2011-present  REI Fellowship Chapter Review Preceptor, University of Colorado, biweekly
2011-2012       Associate Director, Reproductive Endocrinology and Infertility Fellowship, University of Colorado
2011, 2012      Path 8001 Laboratory Medicine, 4th year Medical Student Elective, University of Colorado Denver, School of Medicine, 1 lecture/year
2012                IDPT6003 – Life Cycle, Small Group on Family Planning, 2nd year Medical Student Course, University of Colorado Denver, School of Medicine, 1 small group/year
2012-present   Director, Reproductive Endocrinology and Infertility Fellowship, University of Colorado Doctoral/Master’s Thesis Committee Membership
2011                Isiah Harris, MD (Master of Science in Clincal Sciences), University of Colorado The impact of diet and obesity on reproductive function and physiology: role of PAT proteins in the ovary
2012                Michael Szmyga (Ph.D. in Biology), Albert Einstein College of Medicine Characterization of the Nucleolar Channel System of Human Endometrium
2013                Kenneth Horton (Ph.D. in Biostatistics), University of Colorado School of Public Health Extension of the deconvolution model to allow for multiple subjects estimation in elucidating the mechanisms behind pulsatile hormone secretion

Supervision of Fellow/Junior Faculty Research Projects:
Marie Menke, MD, MPH         Adipokines and Human Endometrium (Co-Preceptor)
Eli Rybak, MD, MPH               Implantation and Nucleolar Channel System (Co-Preceptor)
Zaher Merhi, MD                    Male Body Mass and Embryo Quality for In Vitro Fertilization Success (Primary Preceptor)
Beth McAvey, MD                  Mature Oocyte Yield and In Vitro Fertilization Outcome (Primary Preceptor)
Lauren Roth, MD                    Reproductive Hormonal Alterations in Obesity (Co-Preceptor)
Isiah Harris, MD                     The impact of diet and obesity on reproductive function and physiology: the role of PAT proteins in the ovary (Master’s in Clinical Sciences, Thesis Committee Member)

Supervision of Resident Research Projects
Jennifer Daif, MD                    Predictors of Success for Frozen Embryo Transfer, 2005-2009 (Primary Preceptor)
Edward Nejat, MD                  Health Risks of Obesity, 2010 (Co-Preceptor)
Meleen Chung, MD                Duration of Stimulation and IVF Outcomes, 2009-2010 (Primary Preceptor)
Anatte Karmon, MD                Ethnicity and Perceived Etiology of Infertility, 2009-11 (Primary Preceptor)
Lauren A Ross, MD                Urinary Assay Assessment of Reproductive Hormones in Obesity, 2011-current (Co-Preceptor)
Amanda Ryan, MD                 Etiology of Infertility and Duration of IVF Stimulation, 2012 (Primary Preceptor)
David Kulak, MD                     Ketogenic Diet and Fertility, 2012 (Primary Preceptor)

Supervision of Student Research Projects

Sasha Kucherov         4th year medical student, Albert Einstein College of Medicine, 7/09-6/10 “Aromatase Inhibition and Hypothalamic-Pituitary Output in Women” (Co-preceptor)
Julia Keltz                    4th year medical student, Albert Einstein College of Medicine, 7/09-6/10 “Effects of Male Body Mass on In Vitro Fertilization Outcome” (Primary Preceptor)
Mila Christen Kundu    2nd year veterinary school student, College of Veterinary Medicine Cornell University, summer project at Wake Forest University Primate Center (Winston-Salem, NC), 7/2011-8/2011 “Luteal Function in Vervet Monkeys”, Funded by NICHD R21 (PI:Polotsky)
Katherine Shaum         4th year medical student, University of Colorado MSA “Should mitochondrial nutrients be used for fertility enhancement”, 2012

13. Grant Support

    Grant Support (Ongoing), Principal Investigator:

  1. 1R21HD060944                                                                       $ 365,006        9/10-6/12

NIH- NICHD                                          Polotsky (PI)
Vervet Monkey: Modeling Effects of Diet-Induced Obesity on Reproduction
To establish a translational model of female obesity and reproductive impairment
Role: PI (17%)

  1. 7347 Bayer Droegemueller Award in Clinical Research         $110,000         1/11-12/12

Bayer HealthCare Pharmaceuticals    Polotsky (PI)
Estrogen Sensitivity and Ovulatory Dysfunction in Obesity
To test the hypothesis that HPO axis is abnormally sensitive to estradiol in obesity
Role: PI (50%)

  1. NIH/NICHD Loan Repayment Program                         Amount: $70,000         2011-2013

Extramural Infertility and Contraception Program
Grant Support (Ongoing), Co- Investigator:
5U54HD058155                                   Amount: $1,031,000
Specialized Cooperative Center Program in Reproduction and Infertility Research (SCCPIR)
NIH- NICHD                                          Pollard (PI)                                                       4/1/09-3/31/14
PROJECT 2 – Reproductive Hormonal Alterations in Obesity; Santoro (PI)
The aim is to examine effects of obesity on the hypothalamic-pituitary-ovarian axis in women.
Role: Co-investigator (8%)
Grant Support (Completed):
Empire Clinical Research Investigator Program                                                           7/1/08-6/30/10
New York State Department of Health
The Effects of Body Mass on Reproduction in Adolescent Women
This study examined the interplay of the reproductive and metabolic systems in adolescent girls
Role: Project Director
U01 AG012535           Santoro (PI)                                                                            7/1/07-6/30/10
NIH- NIA
SWAN—the Study of Women’s Health Across the Nation – N.J. site
To follow over 3,000 women longitudinally for psychosocial, gynecological, hormonal, and cardiovascular health outcomes as they traverse menopause
Role: Co-investigator
T32 HD040135            Coutifaris C (PI)                                                                    7/01/05-6/30/07
NIH/NICHD
Effects of modulation of the endometrial cell cycle on xenografted human endometrium
To study endometrial cell cycle via human endometrial xenografts in immunocompromised mice.
Role: PI of subcontract training grant

Bibliography

Original Articles in Peer-Reviewed Journals:

  1. Yankelevich B, Soldatenkov VA, Hodgson J, Polotsky AJ, Mazumder A.  Differential induction of programmed cell death in CD8+ & CD4+ T cells by the B subunit of cholera toxin.    Cellular Immunology. 1996; 68:229-34.
  1. Jain A, Polotsky AJ, Rochester D, Berga SL, Loucks T, Zeitlian G, Gibbs K, Polotsky HN, Feng S, Isaac B, Santoro N. Pulsatile LH amplitude and progesterone metabolite excretion are reduced in obese women. J Clin Endocrinol Metab. 2007; 92:2468-73.
  1. Rybak EA, Polotsky AJ, Woreta T, Hailpern SM, Bristow RE. Fever in myomectomy and hysterectomy patients. Obstet Gynecol. 2008; 111:1137-1142.
  1. Guffanti E, Kittur N, Brodt ZN, Polotsky AJ, Kuokkanen SM, Heller DS, Young SL, Santoro N, Meier UT. Nuclear pore complex proteins. J Cell Sci. 2008; 121:2037-45.
  1. Rochester D, Jain AJ, Polotsky AJ, Polotsky H, Gibbs K, Isaac B, Zeitlian G, Hickmon C, Feng S, Santoro N.  Partial recovery of luteal function after bariatric surgery in obese women. Fertil Steril. 2009; 92:1410-5.
  1. Polotsky AJ, Daif J, Jindal S, Lieman HJ, Santoro N, Pal L. Serum progesterone on the day of hCG predicts clinical pregnancy of sibling frozen embryos. Fertil Steril. 2009; 92: 1880-5.
  1. Polotsky AJ, Hailpern S, Skurnick J, Lo J, Sternfeld B, Santoro N. Association of adolescent obesity and lifetime nulliparity-SWAN, the study of women’s health across the nation. Fertil Steril. 2010; 93:2004-11.
  1. Polotsky AJ, Zhu L, Santoro N, Pollard JW. Lithium chloride treatment induces epithelial cell proliferation in xenografted human endometrium.  Hum Reprod. 2009; 24:1960-7.
  1. Aubuchon M, Lieman H, Stein D, Cohen HW, Isaac B, Adel G, Weitzman V, Tetrokalashvili M, Polotsky AJ, Santoro N. Metformin does not improve the reproductive or metabolic profile in women with Polycystic Ovary Syndrome (PCOS). Reprod Sci. 2009; 16:938-46.
  1. Green RR, Polotsky AJ, Wildman RP, McGinn AP, Lin J, Derby CA, Johnston J, Ram KT, Crandall CJ, Thurston R, Gold E, Weiss G, Santoro N. Menopausal Symptoms within a Hispanic Cohort: SWAN, the Study of Women’s Health Across the Nation. Climacteric. 2010; 13:376-84.
  1. Green RR, Santoro NF, McGinn AP, Wildman RP, Derby CA, Polotsky AJ, Weiss G. The relationship between psychosocial status, acculturation and country of origin in mid-life Hispanic women: data from the Study of Women’s Health Across the Nation (SWAN).Climacteric. 2010;13:534-43.
  1. Keltz J, Zapantis A, Jindal SK, Lieman HJ, Santoro N, Polotsky AJ. Overweight Men: Clinical Pregnancy after ART is decreased in IVF but not in ICSI Cycles. J Assist Reprod Genet. 2010; 27:539-44.
  1. Rybak EA, Szmyga M, Zapantis G, Rausch M, Beshay VE, Polotsky AJ, Coutifaris C, Carr BR, Santoro N, Meier UT. The nucleolar channel system reliably marks the midluteal endometrium regardless of fertility status: a fresh look at an old organelle. Fertile Steril. 2011;95:1385-9.e1.
  1. Lasley B, Crawford SL, Laughlin GA, Santoro N, McConnell D, Crandall C, Greendale G, Polotsky AJ, Vuga M. Circulating Dehydroepiandrosterone Levels in Women with Bilateral Salphingo-Oophorectomy during the Menopausal Transition. Menopause. 2011;18:494-8.
  1. Relwani R, Berger D, Santoro N, Hickmon C, Nihsen M, Zapantis A, Werner A, Polotsky AJ, Jindal S. Semen parameters are unrelated to BMI but vary with SSRI use and prior urological surgery. Reprod Sci. 2011;18:391-7.
  1. Chuang M, Zapantis A, Taylor M, Jindal SK, Neal-Perry GS, Lieman HJ, Polotsky AJ.  Prolonged Gonadotropin Stimulation is Associated with Decreased ART Success J Assist Reprod Genet. 2010; 27:711-7.
  1. Derby CA, Wildman RP, McGinn AP, Green RR, Polotsky AJ, Ram KT, Barnhart J, Weiss G, Santoro N. Cardiovascular risk factor variation within a Hispanic Cohort: SWAN, the Study of Women’s Health Across the Nation. Ethn Dis. 2010;20:396-402.
  1. Kucherov A, Polotsky AJ, Menke M, Isaac B, McAvey B, Buyuk E, Bradford A, Hickmon C, Babbs B, Berga S, Louck T, Santoro N. Aromatase Inhibition Causes Increased Amplitude, but not Frequency, of Hypothalamic-Pituitary Output in Normal Women. Fertil Steril. 2011; 95:2063-6.
  1. McAvey B, Zapantis A, Jindal SK, Lieman HJ, Polotsky AJ. How many eggs are needed to produce an ART baby: is more always better? Fertil Steril 2011;96:332-5.
  1. Karmon A, Hailpern S, Neal-Perry GS, Green R, Santoro N, Polotsky AJ. Association of Ethnicity with Involuntary Childlessness and Perceived Reasons for Infertility: Baseline Data from the Study of Women’s Health Across the Nation (SWAN). Fertil Steril Fertil Steril. 2011;96:1200-1205.e1.
  1. Polotsky HN, Brokhin M, Omry G, Polotsky AJ, Tuttle RM. Iatrogenic hyperthyroidism does not promote weight loss or prevent ageing-related increases in body mass in thyroid cancer survivors. Clin Endocrinology. 2012;76:582-5.
  1. Trussell JC, Christman GM, Ohl DA, Legro RS, Krawetz SA, Snyder PJ, Patrizio P, Polotsky AJ, Diamond MP, Casson PR, Coutifaris C, Barnhart K, Brzyski RG, Schlaff WD, Meacham R, Shin D, Thomas T, Zhang M, Santoro N, Eisenberg E, Zhang H. Recruitment challenges of a multicenter randomized controlled varicocelectomy trial. Fertil Steril. 2011;96:1299-305.
  1. Sermondade N, Faure C, Fezeu L, Lévy R, Czernichow S, on behalf of the Obesity-Fertility Collaborative Group. [Members of Obesity -Fertility Collaborative Group: Jensen TK, Van Wely M, Martini AC, Chavarro J, Koloszar S, Ramlau-Hansen CH, Steegers-Theunissen RPM, Zorn B, Polotsky AJ, Eskenazi B, Magnusdottir EV, Fejes I, Hercberg S] Obesity and increased risk for oligozoospermia and azoospermia. Arch Intern Med. 2012;172(5):440-442.
  1. Polotsky AJ, Allshouse A, Crawford SL, Harlow SD, Khalil N, Santoro N, Legro RS. Relative Contributions of Oligomenorrhea and Hyperandrogenemia to the Risk of Metabolic Syndrome in Midlife Women. J Clin Endocrinol Metab. 2012;97(6):E868-77.
  1. Szmyga M, Rybak EA, Nejat E, Banks EH, Whitney KD, Polotsky AJ, Heller DS, Meier UT. Quantification of nucleolar channel systems: Uniform presence throughout the upper endometrial cavity. Fertil Steril 2012 [Epub ahead of print]
  1. Sermondade N, Faure C, Fezeu L, Shayeb G, Bonde JP, Jensen TK, Van Wely M,  Cao J, Martini AC, Eskandar M, Chavarro JE, Koloszar S, Twigt J, Ramlau-Hansen CH, Borges Jr. E, Lotti F, Steegers-Theunissen RPM, Zorn B,  Polotsky AJ, La Vignera S, Eskenazi B, Tremellen K, Magnusdottir EV, Fejes I, Hercberg S, Lévy R,  Czernichow S. Body mass index in relation to sperm count: an updated systematic review and collaborative meta-analysis. Human Reproduction Update 2012 Dec 12. [Epub ahead of print].
  1. Kundu MC, May MC, Chosich J, Bradford AP, Lasley B, Gee N, Santoro N, Appt SE, Polotsky AJ. Assessment of Luteal Function in the Vervet Monkey as a Means to Develop a Model for Obesity-Related Reproductive Phenotype. Syst Biol Reprod Med. 2013 Jan 2. [Epub ahead of print]
  1. Merhi Z,  Keltz J, Zapantis A, Younger J, Berger D, Lieman HJ, Jindal SK, Polotsky AJ.  Male Adiposity Impairs Clinical Pregnancy Rate by In Vitro Fertilization without Affecting Day 3 Embryo Quality. Obesity 2013 ( In press)

Book Chapters, Letters and Editorials:

  1. Polotsky AJ, Rieder J, Santoro N. Case 31-2006: a girl with severe obesity (Letter).   N Engl J Med. 2007; 356:194-5.
  1. Polotsky AJ, Santoro N. Uterine Disease in Midlife and Beyond: Menopausal Transition and Postmenopause. Aplin et al. The Endometrium: Molecular, Cellular & Clinical Perspectives. 2nd ed, 2007. London: Taylor & Francis.
  1. Santoro N, Polotsky AJ, Rieder J, Pollack S. Nutrition and the Pubertal Transition. Strauss and Barbieri (eds). Yen and Jaffe’s Reproductive Endocrinology. 6th ed, 2009. Philadelphia: W B Saunders Co.
  1. Polotsky AJ, Santoro N. Obesity, Eating Disorders and Menstrual Disturbances. Santoro and Neal-Perry (eds). Amenorrhea: A Case-Based Clinical Guide. 1st ed., 2010. New York: Humana Press.
  1. Polotsky HN, Polotsky AJ. One size may not fit all: Pondering antibiotic dosing in obesity (Guest Editorial) Maturitas. 2010; 66:381-2.
  1. Santoro N, Polotsky AJ, Rieder J, Kondapalli L. Nutrition and Reproduction. Strauss and Barbieri (eds). Yen and Jaffe’s Reproductive Endocrinology. 7th ed, 2012. Philadelphia: W B Saunders Co.
  1. Polotsky AJ.  Does menopause make you heart sick? Not according to MONET. (Guest Editorial) Menopause, 2012;19:722-3.

Scholarly Reviews:

  1. Polotsky AJ, Santoro N. HRT for women with Premature Ovarian Failure. Fertility Today. 2005; 1:62-64.
  1. Polotsky AJ, Santoro N. Menopause and CVD: reproductive hormone exposure affects risk factors. Menopause Management 2007; 16:21-25.
  1. Polotsky AJ, Shur N, Marion RW, Lieman HJ. A flat head in a round world: dispelling common myths about plagiocephaly. Female Patient 2007; 32:46-48.
  1. Polotsky AJ, Houston S. Is there such a thing as “fertility diet”? Contemporary Ob/Gyn 2009; 54: 37-42
  1. Nejat EJ, Polotsky AJ, Pal L. Predictors of chronic disease at midlife and beyond: health risks of obesity. Maturitas 2010; 65:106-11.
  1. Polotsky AJ Obesity and sexuality in men and women: Myths, misconceptions, and the data. Sexuality, Reproduction and Menopause. 2010; 8:7-10.
  1. Polotsky HN, Polotsky AJ.  Metabolic implications of menopause. Semin Reprod Med 2010; 28:426–434.
  1. Polotsky AJ. Amenorrhea caused by extremes of body mass: pathophysiology and sequelae. Contemporary Ob/Gyn 2010; 55:18-23.
  1. Roth LW. Polotsky AJ.  Can we live longer by eating less? A review of caloric restriction and longevity. Maturitas. 2012; 71:315–319.
  1. Polotsky AJ.  Obesity, fertility, and contraception: Disparities among women. Clinical Researcher Perspective. Endocrine News. 2012; 6:28-31.
  1. Harris I, Polotsky AJ.  Conference scene series. What’s New in OB/GYN and Reproductive Medicine, an Update from the annual meeting of Society for Gynecologic Investigation. Women’s Health 2012;8:359-61.
  1. Kulak D, Polotsky AJ. Should the ketogenic diet be considered for enhancing fertility? Maturitas. Maturitas. 2013;74(1):10-3.
  1. Ross A, Polotsky AJ. Metabolic correlates of menopause: an update. Current opinion in Obstetrics & Gynecology. 2012;24(6):402-7.
  1. Shaum K, Polotsky AJ. Nutrition and reproduction: Is there evidence to support a “Fertility Diet” to improve mitochondrial function? Maturitas. 2013 Jan 28. [Epub ahead of print]
  1. Stephens S, Polotsky AJ. Big Enough for an Aromatase Inhibitor?  How Adiposity Affects Male Fertility. Semin Reprod Med 2012 (in press).

Published/Presented Scientific Abstracts:

  1. Yankelevich B, Polotsky AJ, Hodgson J, Verma UN, Mazumder A.  Decreased immunogenicity of long-term bone marrow cultures in vitro and in vivo. American Society of Hematology. Orlando, Florida, December 1996. Blood 1996; 88: S1182.
  1. Polotsky AJ, Daif J, Jindal S, Lieman HJ, Santoro N, Pal L. Successful outcome of a fresh embryo transfer cycle is the most important predictor of success with sibling frozen embryos. ASRM Annual Meeting, Montreal, Canada, October 2005. Fertil Steril. 2005; 84:S177.
  1. Jain A, Polotsky AJ, Gibbs K, Loucks T, Berga SL, Isaac B, Adel G, Zeitlian G, Polotsky H, Santoro N. The reproductive phenotype of obesity: hypogonadotropic hypogonadism due to a selective deficiency in LH pulse amplitude.  Endocrine Society Annual Meeting. Boston, MA, June 2006.
  1. Daif JL, Polotsky AJ, Jindal S, Lieman HJ, Santoro N, Pal L. Post hCG progesterone levels predict success of future FET cycles. ASRM Annual Meeting. New Orleans, LA October 2006. Fertil Steril. 2006; 86:S206.
  1. Rybak EA, Polotsky AJ, Woreta T, Hailpern SM, Bristow RE. Febrile but nonfocal: towards cost-effective evaluation of the myomectomy fever. ASRM Annual Meeting. New Orleans, LA, October 2006. Fertil Steril. 2006; 86:S99.
  1. Polotsky AJ, Hailpern S, Skurnick J, Lo J, Sternfeld B, Santoro N. Adolescent obesity exerts a detrimental effect on lifetime parity independent of adult body mass: baseline data from the SWAN. SGI Annual Meeting. Reno, NV, March 2007. Reproductive Sciences 2007; 14: 225A.
  1. Rochester D, Jain A, Polotsky AJ, Polotsky HN, Gibbs K, Isaac B, Feng S Santoro N. Partial recovery of luteal function after bariatric surgery induced weight loss in women. Endocrine Society Annual Meeting. Toronto, Canada, June 2007.
  1. Polotsky AJ, Hailpern SM, Neal-Perry G, Santoro N. Ethnicity Affects Involuntary Childlessness and Etiology of Infertility: Data from the Study of Women s Health Across the Nation (SWAN). Endocrine Society Annual Meeting. Toronto, Canada, June 2007.
  1. Polotsky AJ, Rochester D, Jain A, Gibbs K, Santoro N.  Normalization of reproductive hormones, insulin resistance and adipokines after bariatric surgery in absence of rise in reverse T3. ASRM Annual Meeting, Washington, DC, October 2007. Fertil Steril 2007; 88:S187.
  1. Kapoor M, Hurwitz JM, Polotsky AJ, Richlin SS, Chi L, Leondires MP. Letrozole in combination with gonadotropins improves ongoing pregnancy rates in poor responders. ASRM Annual Meeting, Washington, DC, October 2007. Fertil Steril. 2007; 88:S100.
  1. Lederman M, Chuang M, Jindal S, Pal L, Polotsky AJ, Santoro N. Three or more COH cycles: a poor prognostic predictor for 1st IVF-ET cycle in patients with unexplained infertility. ASRM Annual Meeting, Washington, DC, October 2007. Fertil Steril. 2007; 88:S148-9.
  1. Polotsky AJ, Zhu L, Santoro N, Pollard JW.  Translating Mouse to Human: A Model of Xenografted Human Endometrium. SGI Annual Meeting. San Diego, CA, March 2008. Reproductive Sciences 2008; 15: S146A.
  1. Green RR, Polotsky AJ, McGinn AP, Derby CA, Wildman RP, Ray L, Ram KT, Weiss G, Santoro N. Variation in menopausal symptoms within a sample of Hispanic women: SWAN, the Study of Women’s Health Across the Nation. SGI Annual Meeting. San Diego, CA, March 2008.  Reproductive Sciences 2008; 15: S309A.
  1. Derby CA, Wildman RP, McGinn AP, Green RR, Polotsky AJ, Ray L, Ram KT, Weiss G, Santoro N. Cardiovascular Risk Factor Variation Within a Hispanic Cohort: SWAN. American Heart Association 48th Cardiovascular Disease Epidemiology and Prevention Annual Conference. Colorado Springs, CO, March 2008.
  1. McGinn AP, Green RR, Polotsky AJ, Derby CA, Wildman RP, Ray L, Ram KT, Weiss G, Santoro N The Relationship between Psychosocial Status, Acculturation and Country of Origin in Mid life Hispanic Women: Data from the SWAN. American Psychosomatic Society Annual Meeting, Baltimore, MD, March 2008.
  1. Polotsky AJ, Rochester D, Jain A, Gibbs K, Zeitlian G, Polotsky H, Isaac B, Santoro N. Improved adipokines, but vitamin D deficiency after bariatric surgery induced weight loss in women. Endocrine Society Annual Meeting. San Francisco, CA, June 2008.
  1. Kapoor M, Polotsky AJ, Leondires MP, Richlin SS, Chi L, Hurwitz JM. Letrozole in combination with gonadotropins improves implantation rates, ongoing pregnancy rates and decreases cancellation rates in poor responders. ASRM Annual Meeting, San Francisco, CA, November 2008.  Fertil Steril. 2008; 90:S33
  1. Kapoor M, Polotsky AJ, Benadiva C, Leondires MP, Richlin SS, Hurwitz JM,. Letrozole can be used in combination with GnRH agonists in poor responders without negating its beneficial effects. ASRM Annual Meeting, San Francisco, CA, November 2008.  Fertil Steril. 2008; 90:S34.
  1. Polotsky AJ, Rochester D, Jain A, Gibbs K, Zeitlian G, Polotsky H, Isaac B, Santoro N. Reduced FSH restraint by markedly depressed inhibin B secretion reverses after surgically induced weight loss in morbidly obese women. ASRM Annual Meeting, San Francisco, CA, November 2008.  Fertil Steril. 2008; 90:S129.
  1. Jindal SK, Polotsky AJ, Buyuk ER, Lieman HJ, Gilligan A. Improved pregnancy rates following introduction of engineering controls of lab air quality. ASRM Annual Meeting, San Francisco, CA, November 2008.  Fertil Steril. 2008; 90:S403.
  1. Santoro N, Polotsky AJ, Jain A, Rochester D, Zeitlian G, Hickmon C, Isaac B. Dysregulation of markers of ovarian reserve in obesity is reversible with surgically induced weight loss. SGI Annual Meeting. Glasgow, Scotland, March 2009. Reproductive Sciences 2009; 16: S93A
  1. Chuang M, Zapantis A, Taylor M, Jindal SK, Lieman HJ, Polotsky AJ.  Gonadotropin stimulation over 12 days in IVF is a negative predictor of livebirth: multivariable analysis of 699 cycles.  ASRM Annual Meeting, Atlanta, GA, October 2009. Fertil Steril. 2009; 92:S80.
  1. Keltz JG, Zapantis A, Jindal SK, Lieman HJ, Santoro N, Polotsky AJ. Male Overweight Infertility Patients: Decreased Clinical Pregnancy after IVF but not after ICSI. SGI Annual Meeting. Orlando, FL, March 2010. Reproductive Sciences 2010; 17: S287A.
  1. Polotsky AJ, Younger J, Chen H, Keltz JG, Chuang M, Zeitlian G, Isaac B, Pollack S, Rieder J, Santoro N. High Molecular Weight Adiponectin as a Marker of Polycystic Ovary Syndrome in Adolescent Girls. SGI Annual Meeting. Orlando, FL, March 2010. Reproductive Sciences 2010; 17: S249A.
  1. Rybak EA, Szmyga MJ, Zapantis G, Rausch M, Beshay VE, Polotsky AJ, Coutifaris C, Carr BR, Santoro N, Meier UT. The Nucleolar Channel System Reliably Marks the Midluteal Endometrium Regardless of Fertility Status: A Fresh Look at an Old Organelle. SGI Annual Meeting. Orlando, FL, March 2010.  Reproductive Sciences 2010; 17: S133A.
  1. Rybak EA, Szmyga MJ, Banks EH, Whitney KD Polotsky AJ, Santoro N, Meier UT. Uniform Expression of the Nucleolar Channel System Throughout the Endometrial Cavity During the Implantation Window. SGI Annual Meeting. Orlando, FL, March 2010. Reproductive Sciences 2010; 17: S139A.
  1. Keltz J, Isaac B, Dicken C, Menke M, Hickmon C, Jindal S, Babbs B, Polotsky A, Pollack S, Santoro N.  LH Surge Induction in Pre-Menarchal Girls:  Positive Neuroendocrine Feedback Occurs Early in Puberty.  Endocrine Society Meeting, San Diego, CA, June 2010.  Endocrine Reviews 2010; 31.
  1. Kucherov A, Polotsky AJ, Menke M, Isaac B, McAvey B, Buyuk E, Bradford A, Hickmon C, Babbs B, Santoro N. Aromatase Inhibition Causes Increased Amplitude but not Frequency of Hypothalamic-Pituitary Output in Normal Women. Endocrine Society meeting. San Diego, CA, June 2010.  Endocrine Reviews 2010; 31:S42.
  1. McAvey B, Zapantis A, Jindal SK, Lieman HJ, Polotsky AJ How many mature eggs from an in-vitro fertilization cycle are enough to take home a baby? ASRM Annual Meeting, Denver, October 2010.  Fertil Steril. 2010; 94:S257.
  1. Merhi Z,  Keltz J, Zapantis A, Jindal SK, Lieman HJ, Polotsky AJ Clinical pregnancy rate but not embryo quality is reduced following IVF−ET in couples with overweight male partner. ASRM Annual Meeting, Denver, October 2010.  Fertil Steril. 2010; 94:S191.
  1. Polotsky AJ, Kucherov A, Bradford A, Lesh J, Babbs B, Chosich J, Santoro N. Obesity: Attenuated Pituitary Responsiveness following GnRH Stimulation. Endocrine Society Meeting, Boston. June 2011.  Endocrine Reviews 2011;32:OR17-12.
  1. Polotsky AJ, Allshouse A, Crawford SL, Harlow SD, Khalil N, Legro RS. History of oligomenorrhea augments the association of hyperandrogenemia with metabolic syndrome: evidence for a PCOS phenotype in the study of women’s health across the nation (SWAN). ASRM Annual Meeting, Orlando, October 2011.  Fertil Steril. 2011; 96:S42.
  1. Karmon A, Hailpern S, Neal-Perry GS, Green R, Santoro N, Polotsky AJ. Attributes not known to cause infertility: a leading perceived etiology of infertility of African−American participants in the study of women’s health across the nation (SWAN). ASRM Annual Meeting, Orlando, October 2011. Fertil Steril. 2011; 96:S115.
  1. Jindal SK, Wang S, Polotsky AJ, McShane P, McGovern PG, Pal L. Negative predictors of embryo quality and live birth: analysis of 77,099 cycles reported to SART. ASRM Annual Meeting, Orlando, October 2011.  Fertil Steril. 2011; 96:S54.
  1. Jindal SK, Chuang M, Berger DS, Polotsky AJ, Santoro N, Pal L. Increase in art-conceived miscarriage and preterm birth rates following hurricane Katrina: analysis of 104,724 cycles reported to SART. ASRM Annual Meeting, Orlando, October 2011. Fertil Steril. 2011; 96:S283.
  1. Davis JB, Koai E, Irobunda HO, Polotsky AJ, Neal-Perry GS. Racial disparities in access and cost for commonly prescribed infertility medications may contribute to disparities in pregnancy outcomes. ASRM Annual Meeting, Orlando, October 2011.  Fertil Steril. 2011; 96:S63.
  1. Aubuchon M, Polotsky AJ, Liu Y, Thomas TR. The impact of supervised weight loss and weight regain on the androgenic sex hormone profile: sex hormone binding globulin is the most sensitive marker of weight fluctuations. ASRM Annual Meeting, Orlando, October 2011. Fertil Steril. 2011; 96:S41.
  1. Kundu MC, May MC, Chosich J, Bradford AP, Santoro N, Appt SE, Polotsky AJ. Luteal function in vervet monkeys (Chlorocebus aethiops). SGI Annual Meeting. San Diego, CA, March 2012.
  1. Polotsky AJ, Allshouse A, Crawford SL, Harlow SD, Khalil N, Kazlauskaite R, Santoro N, Legro RS Incident Metabolic Syndrome Is Not Increased In Women With Hyperandrogenemic Oligomenorrhea Across Menopausal Transition: Longitudinal Follow Up From The Study Of Women’s Health Across The Nation (SWAN). Endocrine Society Meeting, Houston. June 2012. Endocr Rev 2012 33: SAT-4
  1. Ross L, Polotsky AJ, Kucherov A, Bradford A, Lesh J, Chosich J, Santoro N. Aromatase Inhibition Normalizes Luteal Function But Dramatically Reduces Estrone Conjugate Excretion in Obese Women. Endocrine Society Meeting, Houston. June 2012. Endocr Rev 2012 33: SAT-5.
  1. Roth L. Polotsky AJ , Bradford AP, Lesh J, Chosich J, Kohrt W, Santoro N. Relative hypogonadism in obese women is explained by blunted pituitary response to GnRH. Endocrine Society Meeting, Houston. June 2012. Endocr Rev 2012 33: OR25-4
  1. Ross LA, Polotsky AJ, Bradford AP, Lesh L, Chosich J, Santoro N. Female Obesity: Profoundly Reduced Estrogen Excretion After Aromatase Inhibition May Underscore Exaggerated Sensitivity To Estrogen Negative Feedback. ASRM Annual Meeting, San Diego, October 2012.
  1. Stephens SM, Pau KYF, Yalcinkaya TM, Berga SL, Appt SE, Polotsky AJ. Luteinizing Hormone Pulsatility in Vervet Monkeys (Chlorocebus Aethiops): Normative Data for Modeling the Impact of Body Mass on Pituitary Function. ASRM Annual Meeting, San Diego, October 2012.
  1. Ryan AR, Wang S, Alvero R, Polotsky AJ. Prolonged Gonadotropin Stimulation During Art Is Detrimental For All Etiologies of Infertility Except For Women With PCOS: Multivariable Analysis Of 663 Cycles From 12 Years Of Follow-Up. ASRM Annual Meeting, San Diego, October 2012.
  1. Kuokkanen S, Polotsky AJ, Chosich J, Bradford AP, Jasinska A, Phang T, Santoro N, Appt SE. Weight Fluctuations Induce Opposing Changes In Luteal Molecular Signals In Vervet Monkeys. SGI Annual Meeting. Orlando, FL, March 2013.
  1. Polotsky AJ, H. Liu, N. Carlson, J. Chosich, A. Bradford, N. Santoro. Recovery Of Luteinizing Hormone Secretion After Aromatase Inhibition In Obese Women. (OR03-12 Oral Session) ASRM Annual Meeting, Boston, October 2012.
  1. ASRM 2013 Boston. O-261 Oral DISCORDANT ASSOCIATIONS OF LH AND FSH WITH ADIPOSITY IN EUMENORRHEIC WOMEN. A. J. Polotsky, H. Liu, N. Carlson, W. Kohrt, A. Bradford, N. Santoro. (OR02-13 Oral Session)
  1. ASRM 2013 Boston O-442 Oral EVIDENCE OF GNRH ANTAGONIST ESCAPE IN OBESE WOMEN: POTENTIAL EXPLANATION FOR THE HIGH ASSISTED REPRODUCTIVE TECHNOLOGY CANCELLATION RATE. L. W. Roth, E. L. Bradshaw-Pierce, A. A. Allshouse, J. Chosich, A. J. Polotsky, N. Santoro. (OR03-15 Oral Session)
  1. ENDO 2013 Endocr Rev, Vol. 34 (03_MeetingAbstracts): OR19-5 Consistent Ovulation Is Not Enough to Make You Healthy when Approaching Menopause: An Update from SWAN Amanda Ashleigh Allshouse, MS1, Samar El Khoudary, PhD MPH2, Alex Joel Polotsky, MD MS3, Sybil Crawford, PhD4 and Hsiang-Yu Chen, MS
  1. ENDO 2013 Exogenous Estradiol Improves Gonadotropin Sensitivity in Obese WomenAlex J Polotsky, MD, MSc; Huayu Liu, MS; Nichole E Carlson, PhD; Andrew P Bradford, PhD; Jennifer Lesh, BA; Justin Chosich, BA; Nanette Santoro, MD. MON-544 . Endocr Rev, Vol. 34 (03_MeetingAbstracts): MON-544